How Adequan® Works

Reduce. Restore. Repair. Reverse.
Nothing works like Adequan® I.M.

As the only approved equine PSGAG, Adequan® I.M. has a mode of action that helps treat degenerative joint disease (DJD) in multiple ways to keep joints moving. It is proven to help: 1,2

  • Reduce the swelling and inflammation associated with joint disease to improve lameness
  • Restore synovial lubrication that facilitates movement and reduces local inflammation
  • Repair cartilage and rapidly aid in the production of new cartilage
  • Reverse the disease process that leads to the loss of cartilage components by inhibiting harmful enzymes that attack cartilage and synovial fluid

Adequan Equine brown horse riding in autumn HR

Healthy joint

adequan healthyJoint Bone RT Mask

The ends of the bones are covered by articular cartilage which acts as a shock absorber.3

Diseased joint

adequan diseased Joint Bone Right Mask

With cartilage loss, the joint space narrows and bone rubs on bone causing pain, inflammation and decreased range of motion.3

Start early before cartilage is irreparably damaged.

DJD is a progressive condition that worsens if left untreated. This can result in irreversible changes in the joint, including loss of key cartilage components that are essential to healthy mobility. Once a diagnosis is made, a horse needs a treatment plan focused on inhibiting the destructive processes of DJD before mobility is compromised.

Three decades of trust.

For 30 years, leading veterinarians, riders, trainers and horse enthusiasts have relied on Adequan® I.M. to keep their horses moving through competitions, training and everyday life. Words that come from their experiences and hearts communicate the benefits best.

Discover if Adequan® I.M. is the right choice.

Adequan® I.M. Polysulfated Glycosaminoglycan Sterile Injection 100 mg/mL
Adequan® I.M. is recommended for the treatment of non-infectious degenerative and/or traumatic joint dysfunction and associated lameness in horses.
Adequan® I.M. is for veterinary use only. The prescribing information contains complete use information which includes dosing, contraindications, warnings and cautions. Always read, understand and follow label and use directions. PLEASE CONSULT the Full Prescribing Information.
1. Adequan® I.M. (polysulfated glycosaminoglycan sterile injection 100 mg/mL), Package Insert IN99501C. American Regent, Inc.
2. Burba DJ, Collier MA, DeBault LE, Hanson-Painton O, Thompson HC, Holder CL: In vivo kinetic study on uptake and distribution of intramuscular tritium-labeled polysulfated glycosaminoglycan in equine body fluid compartments and articular cartilage in an osteochondral defect model. J Equine Vet Sci 1993; 13: 696-703.
3. Kawcak CE, Barrett MF, Werpy NM, Selberg K. 2016. General Principles of Diagnosis and Treatment. Joint Disease in the Horse. 2nd edition: Pg. 119-133. ISBN: 978-1-4557-5969-9.
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