DIN 01910051
FOR VETERINARY USE ONLY
FOR INTRAMUSCULAR USE IN HORSES
Description: Each mL of Adequan® I.M. contains 100 mg Polysulfated
Glycosaminoglycan (PSGAG) and Water for Injection q.s. Sodium hydroxide
and/or hydrochloric acid added as necessary to adjust pH. Sodium chloride may
be added to adjust tonicity.
Pharmacology: Polysulfated Glycosaminoglycan is chemically similar to the
mucopolysaccharides of cartilaginous tissue. It is a potent proteolytic enzyme
inhibitor and diminishes or reverses the processes which result in the loss of
cartilaginous mucopolysaccharides. PSGAG improves joint function by
stimulating synovial membrane activity, reducing synovial protein levels and
increasing synovial fluid viscosity in traumatized equine joints.
Toxicity: Toxicity studies were conducted in horses. Doses as high as 2,500 mg
were administered intramuscularly to 6 horses twice a week for 12 weeks or a
total of 21 injections. This dosage is 5 times the recommended dosage and
approximately 3 times the recommended therapeutic regimen. Clinical
observations revealed no soreness or swelling at the injection site or in the
affected joint. No animal showed any evidence of abnormality that was related
to Adequan® I.M. treatment as determined by clinical observation and a battery of laboratory tests.
From 100,000 doses used clinically, the reported incidence of side effects is
0.001% (1 case). This reaction consisted of a transient joint flare, occurring
within 24 hours of injection, and resolving within 24 hours with antiinflammatory
therapy.
Indications: Adequan® I.M. is recommended for the treatment of non-infectious
degenerative and/or traumatic joint dysfunction and associated lameness in
horses.
Contraindications: Do not use Adequan® I.M. in horses demonstrating
hypersensitivity to PSGAG.
Warnings: This drug is not to be administered to horses that are to be
slaughtered for use in food. Keep out of the reach of children.
Dosage and Administration: The recommended dose of Adequan® I.M. is
500 mg (1 vial) per 1000 lbs. body weight, given intramuscularly every 4 days
for a total of 8 injections over a 28 day period. The injection site must be
thoroughly cleansed prior to injection. Do not mix Adequan® I.M. with other
drugs or solvents. For intramuscular use only — avoid inadvertent intravascular
administration.
Adverse Reactions: There are no known adverse reactions associated with the
use of Adequan® I.M.
Caution: Avoid inadvertent intravascular administration. Not intended for use in
breeding animals as effects on fertility and reproductive function in mares and
stallions have not been studied.
How Supplied:
Adequan® I.M., PSGAG 100 mg/mL, is available in 5 mL single
dose vials packaged in boxes of 7.
Storage Conditions:
Store at controlled room temperature 18-25°C (64-77°F). Discard unused portion.
AMERICAN REGENT, INC.
ANIMAL HEALTH
Shirley, NY 11967
(1-888-354-4857)
Imported by: Central Sales Limited
1-14 Regan Road
Brampton, ON, L7A 1B9, Canada
IN99501C
Rev. 03/2021C
MG #15651